Buddha says that most of life's suffering is caused by an endless cycle of human craving for impermanent things and states of being, which is dukkha - incapable of satisfying and painful. By trapping ourselves in this continuous state of craving things that don't last, we are caught in an endless cycle of rebirth, dukkha and dying, or samsara. Only by attaining nirvana can we be liberated from this path of suffering.
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